MovDisordV3, Main, Exploration, bibRecord, 001E26

Brain stem pathology in Parkinson's disease: An evaluation of the Braak staging model

Identifieur interne : 001E26 ( Main/Exploration ); précédent : 001E25; suivant : 001E27

Brain stem pathology in Parkinson's disease: An evaluation of the Braak staging model

Auteurs : Ann E. Kingsbury [Royaume-Uni] ; Rina Bandopadhyay [Royaume-Uni] ; Laura Silveira-Moriyama [Royaume-Uni] ; Hilary Ayling [Royaume-Uni] ; Constantinos Kallis [Royaume-Uni] ; William Sterlacci [Autriche] ; Hans Maeir [Autriche] ; Werner Poewe [Autriche] ; Andrew Lees (neurologue) [Royaume-Uni]

Source :

Movement Disorders [ 0885-3185 ] ; 2010-11-15.

RBID : ISTEX:6623685F8973DCA0DE9E322B3B0D4CBF1AFC2990

Descripteurs français

Pascal (Inist)
- Anatomopathologie, Bulbe rachidien, Corps Lewy, Evaluation, Maladie de Parkinson, Modèle, Noyau dorsal, Noyau moteur, Pathologie du système nerveux, Tronc cérébral.

English descriptors

KwdEn :
- Aged, Anatomic pathology, Brain Stem (metabolism), Brain Stem (pathology), Brain stem, Dorsal nucleus, Evaluation, Female, Humans, Immunohistochemistry, Lewy Bodies (metabolism), Lewy Bodies (pathology), Lewy Body Disease (pathology), Lewy body, Lewy body pathology, Male, Medulla oblongata, Middle Aged, Models, Motor nucleus, Nervous system diseases, Neurons (metabolism), Neurons (pathology), Odds Ratio, Parkinson Disease (metabolism), Parkinson Disease (pathology), Parkinson disease, Parkinson's disease, Severity of Illness Index, Tyrosine 3-Monooxygenase (metabolism), alpha-Synuclein (metabolism), dorsal motor nucleus of the vagus, medulla oblongata, pathology staging.
MESH :
- chemical , metabolism : Tyrosine 3-Monooxygenase, alpha-Synuclein.
- metabolism : Brain Stem, Lewy Bodies, Neurons, Parkinson Disease.
- pathology : Brain Stem, Lewy Bodies, Lewy Body Disease, Neurons, Parkinson Disease.
- Aged, Female, Humans, Immunohistochemistry, Male, Middle Aged, Odds Ratio, Severity of Illness Index.

Abstract

The lower brain stem of 25 pathologically‐confirmed Parkinson's disease (PD) cases was examined by alpha synuclein immunohistochemistry to characterize pathological accumulation of alpha synuclein (Lewy‐type α‐synucleinopathy, LTS) in the medulla oblongata, to examine differences between affected regions and test a proposed model of staging of pathology in PD. All cases had LTS in the medulla, including the dorsal motor nucleus of the vagus (dmX), when present. The distribution followed a consistent pattern and appeared to be concentrated in a tyrosine hydroxylase (TH) immunoreactive region, probably representing the dorsal IX/X nuclear complex and the intermediate reticular zone. LTS density was greatest in the dmX. A similar distribution pattern to PD was seen in 14 incidental Lewy body disease (ILBD) cases, five derived from the Queen Square Brain Bank tissue collection and nine identified in separate series of 60 neurologically‐normal individuals, and in three cases with the G2019S mutation of LRRK2. Semiquantitative assessment showed that severity of pathology in the dmX was not correlated with the severity of cortical pathology. Semiquantitative assay of TH and ChAT peptide expression in the medulla showed that TH expression in PD and ILBD did not differ from controls. These findings broadly support the Braak hypothesis of caudo‐rostral development but indicate that the extent of the disease in the cortex and the severity of pathology in the medulla were independent of one another. © 2010 Movement Disorder Society

Url:

https://api.istex.fr/document/6623685F8973DCA0DE9E322B3B0D4CBF1AFC2990/fulltext/pdf

DOI: 10.1002/mds.23305

Affiliations:

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Brain stem pathology in Parkinson's disease: An evaluation of the Braak staging model</title>
<author><name sortKey="Kingsbury, Ann E" sort="Kingsbury, Ann E" uniqKey="Kingsbury A" first="Ann E." last="Kingsbury">Ann E. Kingsbury</name>
</author>
<author><name sortKey="Bandopadhyay, Rina" sort="Bandopadhyay, Rina" uniqKey="Bandopadhyay R" first="Rina" last="Bandopadhyay">Rina Bandopadhyay</name>
</author>
<author><name sortKey="Silveira Oriyama, Laura" sort="Silveira Oriyama, Laura" uniqKey="Silveira Oriyama L" first="Laura" last="Silveira-Moriyama">Laura Silveira-Moriyama</name>
</author>
<author><name sortKey="Ayling, Hilary" sort="Ayling, Hilary" uniqKey="Ayling H" first="Hilary" last="Ayling">Hilary Ayling</name>
</author>
<author><name sortKey="Kallis, Constantinos" sort="Kallis, Constantinos" uniqKey="Kallis C" first="Constantinos" last="Kallis">Constantinos Kallis</name>
</author>
<author><name sortKey="Sterlacci, William" sort="Sterlacci, William" uniqKey="Sterlacci W" first="William" last="Sterlacci">William Sterlacci</name>
</author>
<author><name sortKey="Maeir, Hans" sort="Maeir, Hans" uniqKey="Maeir H" first="Hans" last="Maeir">Hans Maeir</name>
</author>
<author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name>
<affiliation><country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
<author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name>
<affiliation><country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName>National Hospital for Neurology and Neurosurgery</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:6623685F8973DCA0DE9E322B3B0D4CBF1AFC2990</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1002/mds.23305</idno>
<idno type="url">https://api.istex.fr/document/6623685F8973DCA0DE9E322B3B0D4CBF1AFC2990/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000898</idno>
<idno type="wicri:Area/Istex/Curation">000898</idno>
<idno type="wicri:Area/Istex/Checkpoint">000B05</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Kingsbury A:brain:stem:pathology</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:20818670</idno>
<idno type="wicri:Area/PubMed/Corpus">001572</idno>
<idno type="wicri:Area/PubMed/Curation">001572</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001A16</idno>
<idno type="wicri:Area/Ncbi/Merge">002E45</idno>
<idno type="wicri:Area/Ncbi/Curation">002E45</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002E45</idno>
<idno type="wicri:Area/Main/Merge">002262</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:10-0512928</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000818</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002501</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000B83</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Kingsbury A:brain:stem:pathology</idno>
<idno type="wicri:Area/Main/Merge">002770</idno>
<idno type="wicri:Area/Main/Curation">001E26</idno>
<idno type="wicri:Area/Main/Exploration">001E26</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Brain stem pathology in Parkinson's disease: An evaluation of the Braak staging model</title>
<author><name sortKey="Kingsbury, Ann E" sort="Kingsbury, Ann E" uniqKey="Kingsbury A" first="Ann E." last="Kingsbury">Ann E. Kingsbury</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Reta Lila Weston Institute of Neurological Studies, UCL, Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bandopadhyay, Rina" sort="Bandopadhyay, Rina" uniqKey="Bandopadhyay R" first="Rina" last="Bandopadhyay">Rina Bandopadhyay</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Reta Lila Weston Institute of Neurological Studies, UCL, Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Silveira Oriyama, Laura" sort="Silveira Oriyama, Laura" uniqKey="Silveira Oriyama L" first="Laura" last="Silveira-Moriyama">Laura Silveira-Moriyama</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Reta Lila Weston Institute of Neurological Studies, UCL, Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ayling, Hilary" sort="Ayling, Hilary" uniqKey="Ayling H" first="Hilary" last="Ayling">Hilary Ayling</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Reta Lila Weston Institute of Neurological Studies, UCL, Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kallis, Constantinos" sort="Kallis, Constantinos" uniqKey="Kallis C" first="Constantinos" last="Kallis">Constantinos Kallis</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sterlacci, William" sort="Sterlacci, William" uniqKey="Sterlacci W" first="William" last="Sterlacci">William Sterlacci</name>
<affiliation wicri:level="1"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Pathology, Innsbruck Medical University, Innsbruck</wicri:regionArea>
<wicri:noRegion>Innsbruck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maeir, Hans" sort="Maeir, Hans" uniqKey="Maeir H" first="Hans" last="Maeir">Hans Maeir</name>
<affiliation wicri:level="1"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Pathology, Innsbruck Medical University, Innsbruck</wicri:regionArea>
<wicri:noRegion>Innsbruck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name>
<affiliation wicri:level="1"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Pathology, Innsbruck Medical University, Innsbruck</wicri:regionArea>
<wicri:noRegion>Innsbruck</wicri:noRegion>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
<author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Reta Lila Weston Institute of Neurological Studies, UCL, Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName>National Hospital for Neurology and Neurosurgery</orgName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Queen Square Brain Bank for Neurological Disorders, UCL, Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName>National Hospital for Neurology and Neurosurgery</orgName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2010-11-15">2010-11-15</date>
<biblScope unit="vol">25</biblScope>
<biblScope unit="issue">15</biblScope>
<biblScope unit="page" from="2508">2508</biblScope>
<biblScope unit="page" to="2515">2515</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">6623685F8973DCA0DE9E322B3B0D4CBF1AFC2990</idno>
<idno type="DOI">10.1002/mds.23305</idno>
<idno type="ArticleID">MDS23305</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Anatomic pathology</term>
<term>Brain Stem (metabolism)</term>
<term>Brain Stem (pathology)</term>
<term>Brain stem</term>
<term>Dorsal nucleus</term>
<term>Evaluation</term>
<term>Female</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Lewy Bodies (metabolism)</term>
<term>Lewy Bodies (pathology)</term>
<term>Lewy Body Disease (pathology)</term>
<term>Lewy body</term>
<term>Lewy body pathology</term>
<term>Male</term>
<term>Medulla oblongata</term>
<term>Middle Aged</term>
<term>Models</term>
<term>Motor nucleus</term>
<term>Nervous system diseases</term>
<term>Neurons (metabolism)</term>
<term>Neurons (pathology)</term>
<term>Odds Ratio</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Severity of Illness Index</term>
<term>Tyrosine 3-Monooxygenase (metabolism)</term>
<term>alpha-Synuclein (metabolism)</term>
<term>dorsal motor nucleus of the vagus</term>
<term>medulla oblongata</term>
<term>pathology staging</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Tyrosine 3-Monooxygenase</term>
<term>alpha-Synuclein</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain Stem</term>
<term>Lewy Bodies</term>
<term>Neurons</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain Stem</term>
<term>Lewy Bodies</term>
<term>Lewy Body Disease</term>
<term>Neurons</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Anatomopathologie</term>
<term>Bulbe rachidien</term>
<term>Corps Lewy</term>
<term>Evaluation</term>
<term>Maladie de Parkinson</term>
<term>Modèle</term>
<term>Noyau dorsal</term>
<term>Noyau moteur</term>
<term>Pathologie du   système nerveux</term>
<term>Tronc cérébral</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The lower brain stem of 25 pathologically‐confirmed Parkinson's disease (PD) cases was examined by alpha synuclein immunohistochemistry to characterize pathological accumulation of alpha synuclein (Lewy‐type α‐synucleinopathy, LTS) in the medulla oblongata, to examine differences between affected regions and test a proposed model of staging of pathology in PD. All cases had LTS in the medulla, including the dorsal motor nucleus of the vagus (dmX), when present. The distribution followed a consistent pattern and appeared to be concentrated in a tyrosine hydroxylase (TH) immunoreactive region, probably representing the dorsal IX/X nuclear complex and the intermediate reticular zone. LTS density was greatest in the dmX. A similar distribution pattern to PD was seen in 14 incidental Lewy body disease (ILBD) cases, five derived from the Queen Square Brain Bank tissue collection and nine identified in separate series of 60 neurologically‐normal individuals, and in three cases with the G2019S mutation of LRRK2. Semiquantitative assessment showed that severity of pathology in the dmX was not correlated with the severity of cortical pathology. Semiquantitative assay of TH and ChAT peptide expression in the medulla showed that TH expression in PD and ILBD did not differ from controls. These findings broadly support the Braak hypothesis of caudo‐rostral development but indicate that the extent of the disease in the cortex and the severity of pathology in the medulla were independent of one another. © 2010 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Autriche</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Tyrol (Land)</li>
</region>
<settlement><li>Innsbruck</li>
<li>Londres</li>
</settlement>
<orgName><li>National Hospital for Neurology and Neurosurgery</li>
<li>Université de médecine d'Innsbruck</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Kingsbury, Ann E" sort="Kingsbury, Ann E" uniqKey="Kingsbury A" first="Ann E." last="Kingsbury">Ann E. Kingsbury</name>
</region>
<name sortKey="Ayling, Hilary" sort="Ayling, Hilary" uniqKey="Ayling H" first="Hilary" last="Ayling">Hilary Ayling</name>
<name sortKey="Bandopadhyay, Rina" sort="Bandopadhyay, Rina" uniqKey="Bandopadhyay R" first="Rina" last="Bandopadhyay">Rina Bandopadhyay</name>
<name sortKey="Kallis, Constantinos" sort="Kallis, Constantinos" uniqKey="Kallis C" first="Constantinos" last="Kallis">Constantinos Kallis</name>
<name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name>
<name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name>
<name sortKey="Silveira Oriyama, Laura" sort="Silveira Oriyama, Laura" uniqKey="Silveira Oriyama L" first="Laura" last="Silveira-Moriyama">Laura Silveira-Moriyama</name>
</country>
<country name="Autriche"><noRegion><name sortKey="Sterlacci, William" sort="Sterlacci, William" uniqKey="Sterlacci W" first="William" last="Sterlacci">William Sterlacci</name>
</noRegion>
<name sortKey="Maeir, Hans" sort="Maeir, Hans" uniqKey="Maeir H" first="Hans" last="Maeir">Hans Maeir</name>
<name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E26 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001E26 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:6623685F8973DCA0DE9E322B3B0D4CBF1AFC2990
   |texte=   Brain stem pathology in Parkinson's disease: An evaluation of the Braak staging model
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

Brain stem pathology in Parkinson's disease: An evaluation of the Braak staging model

Brain stem pathology in Parkinson's disease: An evaluation of the Braak staging model

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.